【全球快播报】欧盟评估非转基因黑曲霉菌株AS 29-286生产的α-淀粉酶的安全性

时间：2023-07-04 11:26:21 来源: 食品伙伴网

(资料图)

2023年6月30日，欧盟食品安全局就一种食品酶α-淀粉酶（α-amylase）的安全性评价发布意见。

据了解，这种食品酶是由非转基因黑曲霉菌株AS 29-286生产的，旨在用于七种食品制造过程：烘焙过程、果汁生产中的水果和蔬菜加工、果汁以外产品的水果和蔬菜加工、蒸馏酒精生产、生产麦芽糊精的淀粉加工、酿造过程和非葡萄酒醋生产。

经过评估，专家小组认为，在预期的使用条件下，不能排除饮食暴露引起过敏反应的风险，但这种情况发生的可能性很低。根据所提供的数据，小组得出结论，该食品酶在预期的使用条件下不会引起安全隐患。部分原文报道如下：

The food enzyme α-amylase (4-α-d-glucan glucanohydrolase; EC 3.2.1.1) is produced with the non-genetically modified Aspergillus niger strain AS 29-286 by Shin Nihon Chemical Co., Ltd. The food enzyme is considered free from viable cells of the production organism. It is intended to be used in seven food manufacturing processes: baking processes, fruit and vegetable processing for juice production, fruit and vegetable processing for products other than juices, distilled alcohol production, starch processing for the production of maltodextrins, brewing processes and non-wine vinegar production. Since residual amounts of total organic solids (TOS) are removed during distilled alcohol production and starch processing for the production of maltodextrins, dietary exposure was calculated only for the remaining five food manufacturing processes. It was estimated to be up to 2.158 mg TOS/kg body weight (bw) per day in European populations. Genotoxicity tests did not indicate a safety concern. The systemic toxicity was assessed by means of a repeated dose 90-day oral toxicity study in rats. The Panel identified a no observed adverse effect level of 1,774 mg TOS/kg bw per day, the highest dose tested, which when compared with the estimated dietary exposure, resulted in a margin of exposure of at least 822. A search for the similarity of the amino acid sequence of the food enzyme to known allergens was made and four matches with respiratory allergens were found. The Panel considered that, under the intended conditions of use, the risk of allergic reactions upon dietary exposure cannot be excluded, but the likelihood is low. based on the data provided, the Panel concluded that this food enzyme does not give rise to safety concerns under the intended conditions of use.

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【全球快播报】欧盟评估非转基因黑曲霉菌株AS 29-286生产的α-淀粉酶的安全性

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